Minocycline 1‐year therapy in multiple‐system‐atrophy: Effect on clinical symptoms and [11C] (R)‐PK11195 PET (MEMSA‐trial)
Identifieur interne : 000643 ( Main/Exploration ); précédent : 000642; suivant : 000644Minocycline 1‐year therapy in multiple‐system‐atrophy: Effect on clinical symptoms and [11C] (R)‐PK11195 PET (MEMSA‐trial)
Auteurs : Richard Dodel [Allemagne] ; Annika Spottke [Allemagne] ; Alexander Gerhard [Royaume-Uni] ; Alexander Reuss [Allemagne] ; Sylvia Reinecker [Allemagne] ; Nicole Schimke [Allemagne] ; Claudia Trenkwalder [Allemagne] ; Friederike Sixel-Döring [Allemagne] ; Birgit Herting [Allemagne] ; Christoph Kamm [Allemagne] ; Thomas Gasser [Allemagne] ; Martin Sawires [Autriche] ; Felix Geser [Autriche] ; Martin Köllensperger [Autriche] ; Klaus Seppi [Autriche] ; Manja Kloss [Allemagne] ; Martin Krause [Allemagne] ; Christine Daniels [Allemagne] ; Günther Deuschl [Allemagne] ; Silke Böttger [Allemagne] ; Markus Naumann [Allemagne] ; Axel Lipp [Royaume-Uni] ; Doreen Gruber [Allemagne] ; Andreas Kupsch [Allemagne] ; Yansheng Du [États-Unis] ; Federico Turkheimer [Royaume-Uni] ; David J. Brooks [Royaume-Uni] ; Thomas Klockgether [Allemagne] ; Werner Poewe [Autriche] ; Gregor Wenning [Autriche] ; Carmen Schade-Brittinger [Allemagne] ; Wolfgang H. Oertel [Allemagne] ; Karla Eggert [Allemagne]Source :
- Movement Disorders [ 0885-3185 ] ; 2010-01-15.
English descriptors
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Abstract
The aim of the study was to investigate the efficacy of the antibiotic minocycline as a drug treatment in patients with Multiple‐System‐Atrophy Parkinson‐type (MSA‐P). Sixty‐three patients were randomized to minocycline 200 mg/d (n = 32) or a matching placebo (n = 31). The primary outcome variable was the change in the value of the motor score of the Unified Multiple‐System‐Atrophy Rating‐Scale (UMSARSII) from baseline to 48 weeks. Secondary outcome variables included subscores and individual Parkinsonian symptoms as determined by the UMSARS and the Unified‐Parkinson's‐Disease Rating‐Scale (UPDRS). Health‐related quality of life (HrQoL) was assessed using the EQ‐5D and SF‐12. “Progression rate” was assumed to be reflected in the change in motor function over 48 weeks. At 24 weeks and 48 weeks of follow‐up, there was a significant deterioration in motor scores in both groups, but neither the change in UMSARSII nor in UPDRSIII differed significantly between treatment groups, i.e. “progression rate” was considered to be similar in both treatment arms. HrQoL did not differ among the two treatment arms. In a small subgroup of patients (n = 8; minocycline = 3, placebo = 5)[11C](R)‐PK11195‐PET was performed. The three patients in the minocycline group had an attenuated mean increase in microglial activation as compared to the placebo group (P = 0.07) and in two of them individually showed decreased [11C](R)‐PK11195 binding actually decreased. These preliminary PET‐data suggest that minocycline may interfere with microglial activation. The relevance of this observation requires further investigation. This prospective, 48 week, randomized, double‐blind, multinational study failed to show a clinical effect of minocycline on symptom severity as assessed by clinical motor function. © 2009 Movement Disorder Society
Url:
DOI: 10.1002/mds.22732
Affiliations:
- Allemagne, Autriche, Royaume-Uni, États-Unis
- Angleterre, Grand Manchester, Indiana, Tyrol (Land)
- Innsbruck, Manchester
- Université de Manchester, Université de médecine d'Innsbruck
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Rostock</wicri:noRegion><wicri:noRegion>University of Rostock</wicri:noRegion></affiliation></author><author><name sortKey="Gasser, Thomas" sort="Gasser, Thomas" uniqKey="Gasser T" first="Thomas" last="Gasser">Thomas Gasser</name><affiliation wicri:level="1"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Hertie‐Institute, University of Tübingen</wicri:regionArea><wicri:noRegion>University of Tübingen</wicri:noRegion><wicri:noRegion>University of Tübingen</wicri:noRegion></affiliation></author><author><name sortKey="Sawires, Martin" sort="Sawires, Martin" uniqKey="Sawires M" first="Martin" last="Sawires">Martin Sawires</name><affiliation wicri:level="4"><country xml:lang="fr">Autriche</country><wicri:regionArea>Department of Neurology, Medical University of Innsbruck</wicri:regionArea><placeName><settlement type="city">Innsbruck</settlement><region nuts="2" type="region">Tyrol (Land)</region></placeName><orgName type="university">Université de médecine d'Innsbruck</orgName></affiliation></author><author><name sortKey="Geser, Felix" sort="Geser, Felix" uniqKey="Geser F" first="Felix" last="Geser">Felix Geser</name><affiliation wicri:level="4"><country xml:lang="fr">Autriche</country><wicri:regionArea>Department of Neurology, Medical University of Innsbruck</wicri:regionArea><placeName><settlement type="city">Innsbruck</settlement><region nuts="2" type="region">Tyrol (Land)</region></placeName><orgName type="university">Université de médecine d'Innsbruck</orgName></affiliation><affiliation wicri:level="1"><country xml:lang="fr">Autriche</country><wicri:regionArea>European MSA Study Group, Innsbruck Medical University</wicri:regionArea><wicri:noRegion>Innsbruck Medical University</wicri:noRegion></affiliation></author><author><name sortKey="Kollensperger, Martin" sort="Kollensperger, Martin" uniqKey="Kollensperger M" first="Martin" last="Köllensperger">Martin Köllensperger</name><affiliation wicri:level="4"><country xml:lang="fr">Autriche</country><wicri:regionArea>Department of Neurology, Medical University of Innsbruck</wicri:regionArea><placeName><settlement type="city">Innsbruck</settlement><region nuts="2" type="region">Tyrol (Land)</region></placeName><orgName type="university">Université de médecine d'Innsbruck</orgName></affiliation></author><author><name sortKey="Seppi, Klaus" sort="Seppi, Klaus" uniqKey="Seppi K" first="Klaus" last="Seppi">Klaus Seppi</name><affiliation wicri:level="4"><country xml:lang="fr">Autriche</country><wicri:regionArea>Department of Neurology, Medical University of Innsbruck</wicri:regionArea><placeName><settlement type="city">Innsbruck</settlement><region nuts="2" type="region">Tyrol (Land)</region></placeName><orgName type="university">Université de médecine d'Innsbruck</orgName></affiliation><affiliation wicri:level="1"><country xml:lang="fr">Autriche</country><wicri:regionArea>European MSA Study Group, Innsbruck Medical University</wicri:regionArea><wicri:noRegion>Innsbruck Medical University</wicri:noRegion></affiliation></author><author><name sortKey="Kloss, Manja" sort="Kloss, Manja" uniqKey="Kloss M" first="Manja" last="Kloss">Manja Kloss</name><affiliation wicri:level="1"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Neurology, University of Heidelberg</wicri:regionArea><wicri:noRegion>University of Heidelberg</wicri:noRegion><wicri:noRegion>University of Heidelberg</wicri:noRegion></affiliation></author><author><name sortKey="Krause, Martin" sort="Krause, Martin" uniqKey="Krause M" first="Martin" last="Krause">Martin Krause</name><affiliation wicri:level="1"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Neurology, University of Heidelberg</wicri:regionArea><wicri:noRegion>University of Heidelberg</wicri:noRegion><wicri:noRegion>University of Heidelberg</wicri:noRegion></affiliation></author><author><name sortKey="Daniels, Christine" sort="Daniels, Christine" uniqKey="Daniels C" first="Christine" last="Daniels">Christine Daniels</name><affiliation wicri:level="1"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Neurology, University of Kiel</wicri:regionArea><wicri:noRegion>University of Kiel</wicri:noRegion><wicri:noRegion>University of Kiel</wicri:noRegion></affiliation></author><author><name sortKey="Deuschl, Gunther" sort="Deuschl, Gunther" uniqKey="Deuschl G" first="Günther" last="Deuschl">Günther Deuschl</name><affiliation wicri:level="1"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Neurology, University of Kiel</wicri:regionArea><wicri:noRegion>University of Kiel</wicri:noRegion><wicri:noRegion>University of Kiel</wicri:noRegion></affiliation></author><author><name sortKey="Bottger, Silke" sort="Bottger, Silke" uniqKey="Bottger S" first="Silke" last="Böttger">Silke Böttger</name><affiliation wicri:level="1"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Neurology, University of Würzburg</wicri:regionArea><wicri:noRegion>University of Würzburg</wicri:noRegion><wicri:noRegion>University of Würzburg</wicri:noRegion></affiliation></author><author><name sortKey="Naumann, Markus" sort="Naumann, Markus" uniqKey="Naumann M" first="Markus" last="Naumann">Markus Naumann</name><affiliation wicri:level="1"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Neurology, University of Würzburg</wicri:regionArea><wicri:noRegion>University of Würzburg</wicri:noRegion><wicri:noRegion>University of Würzburg</wicri:noRegion></affiliation></author><author><name sortKey="Lipp, Axel" sort="Lipp, Axel" uniqKey="Lipp A" first="Axel" last="Lipp">Axel Lipp</name><affiliation wicri:level="4"><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Wolfson Molecular Imaging Centre, The University of Manchester</wicri:regionArea><placeName><settlement type="city">Manchester</settlement><region type="nation">Angleterre</region><region nuts="2" type="region">Grand Manchester</region></placeName><orgName type="university">Université de Manchester</orgName></affiliation></author><author><name sortKey="Gruber, Doreen" sort="Gruber, Doreen" uniqKey="Gruber D" first="Doreen" last="Gruber">Doreen Gruber</name><affiliation wicri:level="1"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Neurology, University of Berlin</wicri:regionArea><wicri:noRegion>University of Berlin</wicri:noRegion><wicri:noRegion>University of Berlin</wicri:noRegion></affiliation></author><author><name sortKey="Kupsch, Andreas" sort="Kupsch, Andreas" uniqKey="Kupsch A" first="Andreas" last="Kupsch">Andreas Kupsch</name><affiliation wicri:level="1"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Neurology, University of Berlin</wicri:regionArea><wicri:noRegion>University of Berlin</wicri:noRegion><wicri:noRegion>University of Berlin</wicri:noRegion></affiliation></author><author><name sortKey="Du, Yansheng" sort="Du, Yansheng" uniqKey="Du Y" first="Yansheng" last="Du">Yansheng Du</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurology, Indiana University Medical School, Indianapolis, Indiana</wicri:regionArea><placeName><region type="state">Indiana</region></placeName></affiliation></author><author><name sortKey="Turkheimer, Federico" sort="Turkheimer, Federico" uniqKey="Turkheimer F" first="Federico" last="Turkheimer">Federico Turkheimer</name><affiliation wicri:level="1"><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>IMRC Clinical Sciences Centre and Division of Neuroscience, Faculty of Medicine, Imperial College; London</wicri:regionArea><wicri:noRegion>Imperial College; London</wicri:noRegion></affiliation></author><author><name sortKey="Brooks, David J" sort="Brooks, David J" uniqKey="Brooks D" first="David J." last="Brooks">David J. Brooks</name><affiliation wicri:level="1"><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>IMRC Clinical Sciences Centre and Division of Neuroscience, Faculty of Medicine, Imperial College; London</wicri:regionArea><wicri:noRegion>Imperial College; London</wicri:noRegion></affiliation></author><author><name sortKey="Klockgether, Thomas" sort="Klockgether, Thomas" uniqKey="Klockgether T" first="Thomas" last="Klockgether">Thomas Klockgether</name><affiliation wicri:level="1"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Neurology, University of Bonn</wicri:regionArea><wicri:noRegion>University of Bonn</wicri:noRegion><wicri:noRegion>University of Bonn</wicri:noRegion></affiliation></author><author><name sortKey="Poewe, Werner" sort="Poewe, Werner" uniqKey="Poewe W" first="Werner" last="Poewe">Werner Poewe</name><affiliation wicri:level="4"><country xml:lang="fr">Autriche</country><wicri:regionArea>Department of Neurology, Medical University of Innsbruck</wicri:regionArea><placeName><settlement type="city">Innsbruck</settlement><region nuts="2" type="region">Tyrol (Land)</region></placeName><orgName type="university">Université de médecine d'Innsbruck</orgName><placeName><settlement type="city">Innsbruck</settlement><region nuts="2" type="region">Tyrol (Land)</region></placeName><orgName type="university">Université de médecine d'Innsbruck</orgName></affiliation><affiliation wicri:level="1"><country xml:lang="fr">Autriche</country><wicri:regionArea>European MSA Study Group, Innsbruck Medical University</wicri:regionArea><wicri:noRegion>Innsbruck Medical University</wicri:noRegion><placeName><settlement type="city">Innsbruck</settlement><region nuts="2" type="region">Tyrol (Land)</region></placeName><orgName type="university">Université de médecine d'Innsbruck</orgName></affiliation></author><author><name sortKey="Wenning, Gregor" sort="Wenning, Gregor" uniqKey="Wenning G" first="Gregor" last="Wenning">Gregor Wenning</name><affiliation wicri:level="4"><country xml:lang="fr">Autriche</country><wicri:regionArea>Department of Neurology, Medical University of Innsbruck</wicri:regionArea><placeName><settlement type="city">Innsbruck</settlement><region nuts="2" type="region">Tyrol (Land)</region></placeName><orgName type="university">Université de médecine d'Innsbruck</orgName></affiliation><affiliation wicri:level="1"><country xml:lang="fr">Autriche</country><wicri:regionArea>European MSA Study Group, Innsbruck Medical University</wicri:regionArea><wicri:noRegion>Innsbruck Medical University</wicri:noRegion></affiliation></author><author><name sortKey="Schade Rittinger, Carmen" sort="Schade Rittinger, Carmen" uniqKey="Schade Rittinger C" first="Carmen" last="Schade-Brittinger">Carmen Schade-Brittinger</name><affiliation wicri:level="1"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Coordinating Center for Clinical Trials, Philipps‐University of Marburg</wicri:regionArea><wicri:noRegion>Philipps‐University of Marburg</wicri:noRegion><wicri:noRegion>Philipps‐University of Marburg</wicri:noRegion></affiliation></author><author><name sortKey="Oertel, Wolfgang H" sort="Oertel, Wolfgang H" uniqKey="Oertel W" first="Wolfgang H." last="Oertel">Wolfgang H. Oertel</name><affiliation wicri:level="1"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Neurology, Philipps‐University of Marburg</wicri:regionArea><wicri:noRegion>Philipps‐University of Marburg</wicri:noRegion><wicri:noRegion>Philipps‐University of Marburg</wicri:noRegion></affiliation><affiliation wicri:level="1"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Competence Network Parkinson‐Syndrome, Philipps‐University of Marburg</wicri:regionArea><wicri:noRegion>Philipps‐University of Marburg</wicri:noRegion><wicri:noRegion>Philipps‐University of Marburg</wicri:noRegion></affiliation></author><author><name sortKey="Eggert, Karla" sort="Eggert, Karla" uniqKey="Eggert K" first="Karla" last="Eggert">Karla Eggert</name><affiliation wicri:level="1"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Neurology, Philipps‐University of Marburg</wicri:regionArea><wicri:noRegion>Philipps‐University of Marburg</wicri:noRegion><wicri:noRegion>Philipps‐University of Marburg</wicri:noRegion></affiliation><affiliation wicri:level="1"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Competence Network Parkinson‐Syndrome, Philipps‐University of Marburg</wicri:regionArea><wicri:noRegion>Philipps‐University of Marburg</wicri:noRegion><wicri:noRegion>Philipps‐University of Marburg</wicri:noRegion></affiliation></author></analytic><monogr></monogr><series><title level="j">Movement Disorders</title><title level="j" type="abbrev">Mov. Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2010-01-15">2010-01-15</date><biblScope unit="volume">25</biblScope><biblScope unit="issue">1</biblScope><biblScope unit="page" from="97">97</biblScope><biblScope unit="page" to="107">107</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">7E3C331E554F887479122609783881EAE1EEE31D</idno><idno type="DOI">10.1002/mds.22732</idno><idno type="ArticleID">MDS22732</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>PET</term><term>minocycline</term><term>multiple system atrophy</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The aim of the study was to investigate the efficacy of the antibiotic minocycline as a drug treatment in patients with Multiple‐System‐Atrophy Parkinson‐type (MSA‐P). Sixty‐three patients were randomized to minocycline 200 mg/d (n = 32) or a matching placebo (n = 31). The primary outcome variable was the change in the value of the motor score of the Unified Multiple‐System‐Atrophy Rating‐Scale (UMSARSII) from baseline to 48 weeks. Secondary outcome variables included subscores and individual Parkinsonian symptoms as determined by the UMSARS and the Unified‐Parkinson's‐Disease Rating‐Scale (UPDRS). Health‐related quality of life (HrQoL) was assessed using the EQ‐5D and SF‐12. “Progression rate” was assumed to be reflected in the change in motor function over 48 weeks. At 24 weeks and 48 weeks of follow‐up, there was a significant deterioration in motor scores in both groups, but neither the change in UMSARSII nor in UPDRSIII differed significantly between treatment groups, i.e. “progression rate” was considered to be similar in both treatment arms. HrQoL did not differ among the two treatment arms. In a small subgroup of patients (n = 8; minocycline = 3, placebo = 5)[11C](R)‐PK11195‐PET was performed. The three patients in the minocycline group had an attenuated mean increase in microglial activation as compared to the placebo group (P = 0.07) and in two of them individually showed decreased [11C](R)‐PK11195 binding actually decreased. These preliminary PET‐data suggest that minocycline may interfere with microglial activation. The relevance of this observation requires further investigation. This prospective, 48 week, randomized, double‐blind, multinational study failed to show a clinical effect of minocycline on symptom severity as assessed by clinical motor function. © 2009 Movement Disorder Society</div></front></TEI><affiliations><list><country><li>Allemagne</li><li>Autriche</li><li>Royaume-Uni</li><li>États-Unis</li></country><region><li>Angleterre</li><li>Grand Manchester</li><li>Indiana</li><li>Tyrol (Land)</li></region><settlement><li>Innsbruck</li><li>Manchester</li></settlement><orgName><li>Université de Manchester</li><li>Université de médecine d'Innsbruck</li></orgName></list><tree><country name="Allemagne"><noRegion><name sortKey="Dodel, Richard" sort="Dodel, Richard" uniqKey="Dodel R" first="Richard" last="Dodel">Richard Dodel</name></noRegion><name sortKey="Bottger, Silke" sort="Bottger, Silke" uniqKey="Bottger S" first="Silke" last="Böttger">Silke Böttger</name><name sortKey="Daniels, Christine" sort="Daniels, Christine" uniqKey="Daniels C" first="Christine" last="Daniels">Christine Daniels</name><name sortKey="Deuschl, Gunther" sort="Deuschl, Gunther" uniqKey="Deuschl G" first="Günther" last="Deuschl">Günther Deuschl</name><name sortKey="Dodel, Richard" sort="Dodel, Richard" uniqKey="Dodel R" first="Richard" last="Dodel">Richard Dodel</name><name sortKey="Eggert, Karla" sort="Eggert, Karla" uniqKey="Eggert K" first="Karla" last="Eggert">Karla Eggert</name><name sortKey="Eggert, Karla" sort="Eggert, Karla" uniqKey="Eggert K" first="Karla" last="Eggert">Karla Eggert</name><name sortKey="Gasser, Thomas" sort="Gasser, Thomas" uniqKey="Gasser T" first="Thomas" last="Gasser">Thomas Gasser</name><name sortKey="Gruber, Doreen" sort="Gruber, Doreen" uniqKey="Gruber D" first="Doreen" last="Gruber">Doreen Gruber</name><name sortKey="Herting, Birgit" sort="Herting, Birgit" uniqKey="Herting B" first="Birgit" last="Herting">Birgit Herting</name><name sortKey="Kamm, Christoph" sort="Kamm, Christoph" uniqKey="Kamm C" first="Christoph" last="Kamm">Christoph Kamm</name><name sortKey="Kamm, Christoph" sort="Kamm, Christoph" uniqKey="Kamm C" first="Christoph" last="Kamm">Christoph Kamm</name><name sortKey="Klockgether, Thomas" sort="Klockgether, Thomas" uniqKey="Klockgether T" first="Thomas" last="Klockgether">Thomas Klockgether</name><name sortKey="Kloss, Manja" sort="Kloss, Manja" uniqKey="Kloss M" first="Manja" last="Kloss">Manja Kloss</name><name sortKey="Krause, Martin" sort="Krause, Martin" uniqKey="Krause M" first="Martin" last="Krause">Martin Krause</name><name sortKey="Kupsch, Andreas" sort="Kupsch, Andreas" uniqKey="Kupsch A" first="Andreas" last="Kupsch">Andreas Kupsch</name><name sortKey="Naumann, Markus" sort="Naumann, Markus" uniqKey="Naumann M" first="Markus" last="Naumann">Markus Naumann</name><name sortKey="Oertel, Wolfgang H" sort="Oertel, Wolfgang H" uniqKey="Oertel W" first="Wolfgang H." last="Oertel">Wolfgang H. Oertel</name><name sortKey="Oertel, Wolfgang H" sort="Oertel, Wolfgang H" uniqKey="Oertel W" first="Wolfgang H." last="Oertel">Wolfgang H. Oertel</name><name sortKey="Reinecker, Sylvia" sort="Reinecker, Sylvia" uniqKey="Reinecker S" first="Sylvia" last="Reinecker">Sylvia Reinecker</name><name sortKey="Reuss, Alexander" sort="Reuss, Alexander" uniqKey="Reuss A" first="Alexander" last="Reuss">Alexander Reuss</name><name sortKey="Schade Rittinger, Carmen" sort="Schade Rittinger, Carmen" uniqKey="Schade Rittinger C" first="Carmen" last="Schade-Brittinger">Carmen Schade-Brittinger</name><name sortKey="Schimke, Nicole" sort="Schimke, Nicole" uniqKey="Schimke N" first="Nicole" last="Schimke">Nicole Schimke</name><name sortKey="Sixel Ring, Friederike" sort="Sixel Ring, Friederike" uniqKey="Sixel Ring F" first="Friederike" last="Sixel-Döring">Friederike Sixel-Döring</name><name sortKey="Spottke, Annika" sort="Spottke, Annika" uniqKey="Spottke A" first="Annika" last="Spottke">Annika Spottke</name><name sortKey="Trenkwalder, Claudia" sort="Trenkwalder, Claudia" uniqKey="Trenkwalder C" first="Claudia" last="Trenkwalder">Claudia Trenkwalder</name></country><country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Gerhard, Alexander" sort="Gerhard, Alexander" uniqKey="Gerhard A" first="Alexander" last="Gerhard">Alexander Gerhard</name></region><name sortKey="Brooks, David J" sort="Brooks, David J" uniqKey="Brooks D" first="David J." last="Brooks">David J. Brooks</name><name sortKey="Gerhard, Alexander" sort="Gerhard, Alexander" uniqKey="Gerhard A" first="Alexander" last="Gerhard">Alexander Gerhard</name><name sortKey="Lipp, Axel" sort="Lipp, Axel" uniqKey="Lipp A" first="Axel" last="Lipp">Axel Lipp</name><name sortKey="Turkheimer, Federico" sort="Turkheimer, Federico" uniqKey="Turkheimer F" first="Federico" last="Turkheimer">Federico Turkheimer</name></country><country name="Autriche"><region name="Tyrol (Land)"><name sortKey="Sawires, Martin" sort="Sawires, Martin" uniqKey="Sawires M" first="Martin" last="Sawires">Martin Sawires</name></region><name sortKey="Geser, Felix" sort="Geser, Felix" uniqKey="Geser F" first="Felix" last="Geser">Felix Geser</name><name sortKey="Geser, Felix" sort="Geser, Felix" uniqKey="Geser F" first="Felix" last="Geser">Felix Geser</name><name sortKey="Kollensperger, Martin" sort="Kollensperger, Martin" uniqKey="Kollensperger M" first="Martin" last="Köllensperger">Martin Köllensperger</name><name sortKey="Poewe, Werner" sort="Poewe, Werner" uniqKey="Poewe W" first="Werner" last="Poewe">Werner Poewe</name><name sortKey="Poewe, Werner" sort="Poewe, Werner" uniqKey="Poewe W" first="Werner" last="Poewe">Werner Poewe</name><name sortKey="Seppi, Klaus" sort="Seppi, Klaus" uniqKey="Seppi K" first="Klaus" last="Seppi">Klaus Seppi</name><name sortKey="Seppi, Klaus" sort="Seppi, Klaus" uniqKey="Seppi K" first="Klaus" last="Seppi">Klaus Seppi</name><name sortKey="Wenning, Gregor" sort="Wenning, Gregor" uniqKey="Wenning G" first="Gregor" last="Wenning">Gregor Wenning</name><name sortKey="Wenning, Gregor" sort="Wenning, Gregor" uniqKey="Wenning G" first="Gregor" last="Wenning">Gregor Wenning</name></country><country name="États-Unis"><region name="Indiana"><name sortKey="Du, Yansheng" sort="Du, Yansheng" uniqKey="Du Y" first="Yansheng" last="Du">Yansheng Du</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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